Carcinoma Mucoepidermoide de Glándulas Salivales Intraoral: Factores Clínicos y Patológicos e Inmunoexpresión de c-erbB-2 en 29 Casos. Vanessa Fátima. Publisher: El propósito de este estudio es presentar la casuística del carcinoma mucoepidermoide de glándulas salivales de pacientes diagnosticados en el. English: Tumors of the salivary glands represent % of head and neck neoplasms. Mucoepidermoid carcinoma (MEC) is the most common epithelial.

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Carcinoma of the parotid and submandibular glands a study of survival in patients.

Mucoepidermoid carcinoma of intraoral salivary glands. Salivary gland tumors in children and adolescents: Mucoepidermoid carcinoma of the major swlivales glands: Casilla D Temuco – Chile Tel.: Future investigations could benefit from this study, helping to provide further strategies for more efficient management of MECs.

Carcinoma mucoepidermoide

walivales Blocking of endogenous avidin-botin activity in immunohistochemistry. The effects of age, gender, anatomic localization, tumor size, clinical stage, histological grade, recurrence, metastasis, compromised surgical margins and treatment on clinicopathological outcomes were investigated.

Review of the literature and clinicopathological analysis of ssalivales patients. Mucoepidermoid carcinoma of the salivary mucoepifermoide. However, its prognostic value should be validated with clinical studies and survival analyses. The disease-free interval for recurrences and metastases ranged from 22 to months and 22 to months, respectively. The tumoral histological grade was associated with the ki67 expression, relevant prognosis factors in MEC.

Our data suggest that further investigation is indeed warranted to better assess the role of c-erbB-2 immunoexpression in pathogenesis of mucoepidermoid carcinomas of salivary glands.

Am J Surg Pathol. In the present study, was set out to examine MEC behavior and patient outcomes to provide additional information on potential factors that could significantly glandula the prognosis of these tumors. High grade tumors, on the other hand, seem to arise more often in major salivary glands Kokemueller et al. Low grade tumors seem to arise more often in minor salivary glands, which according to some authors are detected at gkandulas stages, probably due to the less aggressive growth in addition to a better visible tumor site.


There is a growing consensus that an aggressive surgical approach with adjuvant radiotherapy must always be considered for more advanced cases that present with a high histological grade, positive margins and cervical involvement.

Histological classification of salivary gland tumours. Complementary studies to compare carbohydrates salifales the normal salivary glands must be carried out because subtle alterations in tumor cells glycosylation can influence their biological behavior.

However, many studies found that benign and malignant salivary gland neoplasms with evidence of myoepithelial lineage do not overexpress c-erbB-2 protein which support the view that this growth receptor is not involved in their pathogenesis Rosa et al. Through a mucoepudermoide follow-up period in present study was highlight the relevance of primary anatomical site, tumor size and metastasis as useful prognostic factors that may affect survival in patients with a primary diagnosis of head and neck mucoepidermoid carcinomas.

The palate was the most commonly affected site, with 21 cases International Journal of Morphology. This study aimed to investigate prognostic factors that may affect survival in patients with a primary diagnosis of head and neck mucoepidermoid carcinomas. Studies on intra-oral MEC have shown similar results with a higher percentage of low grade tumors Kokemueller et al.

MECs were staged according to the TNM classification of malignant tumors, 12 and minor salivary gland tumors were staged salivsles to their site of origin in a similar fashion to squamous cell carcinomas.

This overexpression may be due to the process envolving histogenesis and celular differentiation. However, remote access to EBSCO’s databases from non-subscribing institutions is not allowed if the purpose of the use is for commercial gain through cost reduction or avoidance for a non-subscribing institution.


Histopathologic grading of salivary gland neoplasms. Salivary gland neoplasms, mucoepidermoid carcinoma, disease-free survival.

Briefly, 4 um sections were dewaxed in xylene and hydrated with graded ethanol. Intraoral Mucoepidermoid Carcinoma of Salivary Glands: Blocking of endogenous peroxidase and avidin-biotin activity were performed Miller et al. However, users may print, download, or email articles for individual use.

Carcinoma mucoepidermoide de glándulas salivales en Brasil: relación clinicopatológica

This abstract may be abridged. It is composed of mucous, epidermoid, intermediate, columnar and clear cells. Histological features and prognosis of patients with mucoepidermoid carcinoma of the parotid gland. Oral Oncol, 41 1: The follow-up acrcinoma in this salivles ranged from 6 to months.

Immunohistochemical study of c-erbB-2 oncoprotein overexpression in human major salivary gland carcinoma: However, as the MEC is the most common malignant tumor of salivary glands in young people this observation is in accordance with the literature as also the female predilection Auclair et al.

Additionally, a significant influence on prognosis was observed in DFS curves depending on the primary anatomical site. In our series, patients demonstrated an earlier average age of occurrence, with a peak of incidence in the third and fourth decades of life, whereas previous studies described a prevalence in fifth and sixth decades df life Auclair et al.

Tumors were stratified into three groups: Muc4 saoivales erbb2 expression in major and minor salivary gland mucoepidermoid carcinoma.

Treatment and survival outcomes based on histologic grading in patients with head and neck mucoepidermoid carcinoma.